LOD LOQ and linear regression

I have a practical question regarding the determination of the LOD and LOQ. I have data for dose response curves for many samples in several tests. Table: Assay, Conditions, Sample, Concentration, response. The table contains a number of points in the TOP and BOTTOM of this response. Do you know of a tool that would determine these parameters based on SLOPE and Sy (at least to determine these SLOPE and Sy) for each combination: Assay, Conditions, Sample, Concentration also filtering out points where there is no response or where there is a maximum response, fitting a linear regression to them and determining these parameters of the fitted curve? Thank you in advance for your help